Terapio is developing delivery technologies capable of delivering biologics, small molecules, nucleic acids, or imaging agents and markers for diagnostics. The various cargos are delivered throughout the body and, most significantly, across the blood-brain barrier (BBB) to the central nervous system (CNS). This innovative technology uses the RLIP76 protein to augment the transport of cargo packaged in a carrier system. RLIP76, an endogenous protein, enhances cellular uptake by the brain and other organs to support the delivery of functional and clinically effective cargo.

As shown above, cargo is packaged in a carrier system where the RLIP76 protein (green) enhances delivery and uptake to organ cells (top figure) or across the blood-brain barrier (BBB) to brain cells (bottom figure).

Terapio is developing a pipeline of applications based on the RLIP76 delivery platform.